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In case both R and H aretolerated—do not restart Z but prolong therapywith R and H to 9 months. Acute complications of metabolic acidosis may encompasshyperventilation as well as severe changes of serum electrolytes and acid base balanceleading to cardiac arrhythmias necessitating immediate hospital treatment withintravenous alkalinizing. A history ofprior gallstone disease (biliary colic or choledocholithiasis) should be ascertained.
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